IVETh

• Biotherapy
• Bioproduction
• Diagnostics
• Bioengineering
• Machine learning
• Training and education

• Multimodal characterisation
• Quality control
• Regulations
• Data analysis
• Automation

• Nanosight NS300 + autosampler – Malvern Panalytical
• VideoDrop – Myriade
• ExoView R100 – NanoView
• Nucleocounter® NC-200™ – Chemometec
• Asymetrical flow field – flow fractionation (A4F) – Wyatt Technology
• Microscope optique EVOS M5000 – ThermoFisher
• CellInsight – CX7-LZR – High content screening (HCS) – ThermoFisher
• SAFe 360 – Abbelight
• Raman microscope DXR3xi – ThermoFisher
• Raman tweezers microscope – by Sergei Kruglik
• Flow NanoAnalyzer – NanoFCM
• MESO QuickPlex SQ 120 – Meso Scale Discovery
• Ultracentrifuges Optima Max et XE
• DasBox – Eppendorf
• Confocal microscope Ax Ti2E – Nikon
• ZetaView Quatt colocalization – Particle Metrix
• Filtration à flux tangential (TFF) (several available systems)

Sites affiliated to Université Paris Cité (UPC)

• Institut de Psychiatrie et Neurosciences de Paris (IPNP) – UMR-S 1266
  Plateforme de Biochimie et Biophysique
  David TARESTE, Erwan BOEDEC, Kristina NIORT
  Site de Saint Anne, 102-108, rue de la santé – 75014 Paris
  kristina.niort@inserm.fr
• Research center on inflammation (CRI) – UMR-S 1149
  Extracellular Vesicles Platform
  Pierre-Emmanuel RAUTOU, Marion TANGUY
  Site Bichat, 16 rue Henri Huchard – 75890 Paris Cedex 18
  marion.tanguy@inserm.fr
• Paris Cardio-Vascular Research center (PARCC) – UMR 970
  Chantal BOULANGER
  Site HEGP, 56 rue Leblanc – 75015 Paris

Partners

• NABI: Nanomedicine, Extracellular Biology, Integratome and Innovations in Health

Objectives: 

Development of processes and methods for the bioproduction, engineering and characterisation of EVs (extracellular vesicles) and nanovectors for therapy and diagnosis.

• • Promoting the technological maturity level (TRL) and facilitating market access for EV-based healthcare products, accelerating the technological maturation of medical innovations based on EVs and nanovectors for treatment and diagnosis from the laboratory to the patient’s bedside.

Missions:

• • EV bioproduction: developing innovative EV bioproduction processes aimed at increasing production yields and optimising therapeutic efficacy and biodistribution using biophysical, genetic engineering and screening approaches.
  • Multimodal characterisation: multidisciplinary, multiscale, and multimodal approach to characterising biofluid EVs or bioproduct EVs to develop new diagnostic or prognostic solutions (from liquid biopsies) or new quality control methods (from bioproducts).

• • Technology and clinical transfer: promoting the TRL ramp-up and technology transfer to CDMOs of bioproduction and biotherapy development projects (processes, prototypes, biomedicines, etc.), as well as the discovery of new diagnostic, prognostic or therapy monitoring biomarkers.

• • Training: Developing specifically adapted training programmes (e.g. INSERM 273 workshop)

• • Providing an environment conducive to the development of start-ups

• • Offers: technological and innovation consultancy, services, project support, collaboration contracts (with shared intellectual property), customised training. Each of these services is tailored to the specific scientific, technical, and regulatory requirements of each research and development project involving extracellular vesicles and nanovectors.

• • Ongoing

Academics

• CARN: (ANR – PEPR Bioproduction/ biotherapy). Development of biotherapies based on the local delivery of therapeutic RNA by functionalized hybrid vesicles for musculoskeletal regeneration.
• Bacter-EV-booster: (ANR – PEPR Biotherapies bioproduction) Multidisciplinary approach to stimulate the bioproduction and engineering of EVs in gram-positive bacteria for anti-inflammatory therapeutic purposes.
• StromaEV: (ANR – PEPR Bioproduction/ biotherapy) From the production of extracellular vesicles isolated from IPS-derived mesenchymal stromal cells to clinical application
• MAESTROVE: (ANR) A matrix therapy to optimise MSC-derived extracellular vesicles for cerebral protection and repair after ischaemia.
• Nanomilk: (ANR) Contamination of milk by metallic nanoparticles: mother-infant transfer and the role of extracellular vesicles

Industrials

• EVerZom: spinoff of MSC Med
• Abbelight: development of nanoscopy for quality control of extracellular vesicles
• Myriade: development of interferometric analysis of nanoparticles for quality control of extracellular vesicles and mitochondria.