Coordination
INSERM délégation Occitanie Méditerranée
Director
Danièle NOEL
Contact : obbi.integrator@inserm.fr
Areas of application
- Regenerative Medicine
- MTI
- In vitro disease modelling
- Efficacy studies of drug candidates
- Toxicity studies of drug candidates
- Host-pathogen interaction studies
- Personalised medicine
- Tissue regeneration
- Diagnostics
- Prognosis
- Drug Delivery
- Immune Modulation
- Vaccination
Expertise
- Extracellular vesicles
- Organoids
- In vitro modelling
- Regenerative medicine
- Biomarkers
- Biomanufacturing quality control
Facilities of interest
- Ambr 250 Modular Bioreactor (Sartorius)
- Nucleocounter NC-200 (Chemometec)
- EVOS M5000 Microscope (Thermo Fisher Scientific)
- KrosFlo KR2i TFF (Repligen)
- Ultracentrifuge Optima XE90 – SW 32Ti (Beckmann Coulter)
- Videodrop (Myriade)
- Zetaview (ParticleMetrix)
- Flow Cytometer NanoAnalyzer (NanoFCM)
- Super-resolution Nanoimager (ONI)
- Qubit 4 fluorimeter (Invitrogen)
- Opera Phenix (Revvity)
- Nanointendor Pavone (automatic measurement of biomechanical properties of 3D objects)
- Digital PCR (absolute quantification of transcripts)
- Light sheet microscopy
- Virtual reality visualisation (Zeiss partnership)
- CLARIOstar Plus plate reader
- Room L
Associated research structures
- INSERM U1183,IRMB Montpellier
- INSERM U1310,RESTORE, Toulouse
- INSERM U1220, IRSD, Toulouse
Who are we?
What do we do
Objectives:
- Develop GLP-compatible processes for bioproduction and characterisation of extracellular vesicles.
- Optimize, standardize and create existing and new bioproduction methods for organoid cultures.
- Guarantee reproducibility and transfer to industry.
- Implement high-resolution quality control (QC).
- Participate in the development of biotherapies based on extra-cellular vesicles and organoids.
Missions:
- Provide access to state-of-the-art equipment and expertise in the bioproduction of organoids and extracellular vesicles.
- Provide an environment that fosters the development of GLP-compliant biomanufacturing processes.
- Create a meeting place for academics and industry to stimulate innovation and support start-ups
- Create biobanks of organoids derived from healthy cells and from patients suffering from various diseases (inflammation, cancer, rare diseases, etc.).
- Set up national and/or international partnerships involving start-ups, biotechs and pharmaceutical companies.
Quality Label
Ongoing
Examples of funded projects
Academics
Industrials
Our partners
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