Introduction
For over 25 years, ViVeM has been developing processes for the production and purification of viral vectors, whether derived from adenovirus, adenovirus-associated virus (AAV) or lentivirus (LV). These vectors are produced for in vitro and in vivo gene transfer applications, both for basic research and for the evaluation of therapeutic strategies for numerous diseases (genetic diseases, cancer). ViVeM’s links with TaRGeT’s research teams enable it to offer technologies, processes and strategies at the cutting edge of innovation
Expertise
- Custom design (serotype, transgene promoter, codon optimization), cloning, plasmid production
- Research grade production (cesium gradient purification)
- Formulation
- Process development, upstream (USP) and downstream (DSP) optimization
- Feasibility studies, small-scale productivity
- Scale-up to 50L of GMP-compatible processes
- Technology transfer to CDMOs
- Analytical characterization: titration, infectivity, purity, residual contaminants, transgene expression, potency tests, stability ….
- Evaluation of innovative technologies
Service offer
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