AAP / AMI
Introduction

OBBI is a unique national service unit dedicated to providing know-how, expertise and innovation to accelerate and facilitate the development of organoid and EV bioproduction. OBBI interacts with biotech, industrial and academic partners to meet the need for robust, reproducible processes in this key, innovative sector for the future of medicine. Located in Montpellier and Toulouse, OBBI offers advanced development, optimisation, standardisation and characterisation capabilities for the production of organoids and extracellular vesicles (EVs) for research and industrial applications (see catalogue).

This expertise and know-how covers the entire biomanufacturing value chain, from fundamental research to pre-industrial production.

OBBI is a service unit managed by INSERM
The director is Danièle Noël, DR1 Inserm (IRMB Institute, Montpellier)
The deputy director is Louis Casteilla, Prof UT3 (RESTORE Institute, Toulouse)

Expertise

Multidisciplinary expertise in biomanufacturing

OBBI draws on advanced know-how in the bioproduction of EVs and organoids, as well as in the implementation of standardised processes that comply with Good Manufacturing Practice (GMP). Thanks to the synergy between the research teams in Toulouse and Montpellier, OBBI is able to offer an integrated solution to the most complex scientific and industrial challenges.

Expertise in quality control and standardisation

OBBI excels in the implementation of high-resolution quality controls to guarantee the reproducibility and industrialisation of processes. These activities include advanced characterisation of cells, whether mature or progenitor, generating organoids or producing EVs, and of the 3D objects themselves, meeting the strict requirements of the pharmaceutical industry and regulatory agencies.

Collaborative, cross-disciplinary expertise

With its collaborative and integrated governance, OBBI facilitates interactions between academic and industrial partners. Its strategic collaborations with key industrial players enable it to bridge the gap between fundamental research and industrial applications. Thanks to its expertise, OBBI offers solutions to help validate and industrialise bio-therapeutic innovations, while guaranteeing quality and reproducibility in line with industrial requirements.

Infrastructures of excellence and network

Based in the Occitanie region, OBBI is part of a very dynamic industrial and academic ecosystem, with many researchers and clinicians in Montpellier and Toulouse who have been working in the field of biotherapies for several years and have acquired expertise and complementary skills in biomanufacturing. OBBI proposes to capitalise on this know-how by making it available to players in industry and academia, with the shared aim of providing innovative solutions for tomorrow’s treatments. Through these players, OBBI also interacts closely with national networks in the field (PEPR, GDR organoïdes, France Biolead, FSEV, EVOLVE) as well as European partners.

A strategic position in the Occitanie region and nationally

OBBI draws on the region’s ecosystem of academic and business structures in the field of biotherapies, bioproductions and regenerative medicine, which has been identified as a major cluster at national level. By integrating local skills and existing infrastructures, OBBI will play a key role in the national and European landscape of organoid and EV bioproduction, with the aim of encouraging the emergence of technological innovations and public-private partnerships.

Service offer
  • Development, standardisation and optimisation of processes for the bioproduction of extracellular vesicles
  • Development, standardisation and optimisation of processes for the bioproduction of organoids
  • Physicochemical and functional characterisation of EVs and organoids
  • Standard and advanced quality controls
  • Standardised production complying with GMP requirements
  • Provision of instrumental facilities: Access to state-of-the-art equipment, as well as the possibility of serving as a beta-tester site for new technologies.
  • Strategic consultancy: Support for industrial and academic partners in developing EV and organoid biomanufacturing strategies, technology transfer and regulatory compliance
  • Training
For more information, please contact

Danièle Noël, DR1 INSERM – Director

daniele.noel@inserm.fr

+33 4 67 33 04 73

Louis Casteilla, PU UT3 – Deputy Director

louis.casteilla@inserm.fr

+33 5 34 60 95 01

Montserrat Bosch Grau – Business Manager

obbi.integrator@inserm.fr;

montserrat.bosch-grau@inserm.fr

+33 6 58 38 48 49