AAP / AMI
Introduction

The industrial integrator TIBH is the result of the expertise of 3 organisations – TBI, TWB and CRITT-Bioindustries – in the field of industrial biotechnologies, and is part of the National Strategy for Accelerating Biotherapies and Bioproduction of Advanced Therapies of the France 2030 programme.
TIBH’s mission is to address the challenges of biomanufacturing in the healthcare sector, and in particular to propose innovative solutions, de-risk and accelerate the development of innovative therapies and bioprocesses.
TIBH is the only national healthcare integrator that aims to develop alternatives to conventional biomanufacturing by using microbial cell factories and designing appropriate bioprocesses at reduced cost.
TIBH plays a key role in securing and developing biomedical products in France and Europe. Drawing on its know-how, TIBH offers innovative scientific and technical strategies tailored to the needs of the industry. TIBH also stands out for its support in strengthening and validating proofs of concept established by academics and start-ups.

Thanks to its expertise, which is recognised by the industrial and academic ecosystems, TIBH has generated strong demand for collaboration: 20 opportunities, including 10 applications submitted, resulting in funding for 5 projects. The implementation of these projects is aimed, for example, at reducing the cost of producing monoclonal antibodies, optimising messenger RNA generation using new production frames, and developing on-line analysis and control systems.

Expertise

Developing innovative alternatives to traditional bioproduction by exploiting microbial cell factories and developing optimised bioprocesses tailored to specific needs.

  • Design and engineering of proteins: increasing the efficiency of molecules
  • Design and engineering of microbial strains: new production systems; selecting the systems best suited to the constraints of bioproduction in healthcare. Adapting genetic and metabolic engineering strategies to increase yield;
  • Bioprocess development, including biocatalysis (USP & DSP): optimising bioprocesses for industrialisation.
  • Scale-up
  • Use of OMICS to ensure efficient and rapid development
  • Implementation of public/private partnerships
Service offer

A service offer that listens to the needs of industry and is part of the biomedicine value chain, from TRL 0 to TRL 6.

  • Enzymes and proteins :
    • Screening
    • Directed evolution
    • In silico design
    • Structure/activity relationships
    • Immobilisation of enzymes / biocatalytic process
  • Microbial diversity
    • Screening of various variants
    • Identification
  • Development of industrial chassis
    • Genetic and metabolic engineering of conventional and non-conventional cell factories
    • Development of genetic tools adapted to synthetic biology
  • DSP
    • Separation method
    • Concentration
    • Purification
    • Crystallisation, Lyophilisation
    • Process development & optimisation (50ml to 10L)
    • Scale-up
    • Batch production for in vitro / ex vivo testing
    • Transfer of processes to a CDMO
  • SETTING-UP & MANAGEMENT of R&D programmes
  • SUPPORT for the development and hosting of START-UPS
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